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Abstract. The relation of science and religion is one of the most important interdisciplinary issues in the  world  from  the  past  to  the  present.  Any  kinds  of  religion  generally  brought  about  a  new  challenging discussion with science; Islam and its scriptures are not exceptions in this case. The Qur'an as a main Islamic scripture has a direct relation with science and scientific matters according to many thinkers' declarations; it is obvious that there are opponents for this subject, on the other side. The purpose of this paper is to examine main  categories  of  the  relation  of  science  and  religion  and  then  assess  and  reveal  the  opponents  and adherents' beliefs regarding the relation of religion and science and relation of science and the Qur'an with a  precise  library  method.  This  paper  provided  readers  with  the  role  and  dignity  of  science  in  Islam  and remarkable viewpoints of great thinkers regarding the issue of the relation of science and the Qur'an.